Why a trendy weight-loss supplement is not ‘nature’s Ozempic’ (2024)


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Savannah Crosby had been gaining weight despite tracking her calories and hitting the gym. Looking for answers, the 34-year-old Texas resident fell down an internet rabbit hole that led her to berberine: a yellow, bitter-tasting chemical found in plants that some claim helps weight loss.

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“After seeing how cheap berberine was, I figured I didn’t have anything to lose,” said Crosby, who has been chronicling her weight-loss journey on TikTok. More than two months later, Crosby said she has lost eight pounds.

Others on social media are making similar claims, and some have even dubbed the supplement “nature’s Ozempic,” a misleading comparison to the Type 2 diabetes drug that has gained popularity as a weight-loss treatment.

The catchy comparison has taken off. On TikTok, the hashtag #berberine has 73 million views and counting


“The term ‘nature’s Ozempic’ is pure marketing, and implies that the berberine chemical is similar in any shape, form, or mechanism to Ozempic, and it’s not,” said F. Perry Wilson, a Yale School of Medicine physician and epidemiologist who studies the supplement industry.

“Supplements really are the wild west,” Wilson said. “Just because a supplement says it’s natural and has a price that doesn’t break the bank, doesn’t mean it works or that it’s safe.”

Here’s everything to know about the berberine’s risks, side effects, and the research studying whether it actually works.

What is berberine?

Berberine is a chemical found in several plants, such as European barberry, goldenseal, goldthread and tree turmeric, that has been extracted and sold as a supplement in powder or pill form.

You can find berberine supplements at your health store, as well as major retailers. Bottles with 60 capsules, about a month’s supply, can range anywhere from $12 to $50.

What is berberine normally used for?

Berberine has been used in traditional Chinese medicine to treat bacterial diarrhea due to its antimicrobial properties. Some research suggests the supplement can lower blood sugar and decrease insulin resistance in people with Type 2 diabetes. Studies have also suggested that berberine can lower cholesterol and reduce blood pressure.


Still, much of the research on berberine is limited, of low quality and ultimately inconclusive, said Carol Haggans, a registered dietitian and consultant for the NIH’s Office of Dietary Supplements. Many studies include small sample sizes and short study periods or have analyzed berberine in combination with other dietary supplements.

“Although berberine has been studied for a variety of different things, I wouldn’t say it’s been proven for the treatment of anything,” Haggans said.

Can berberine help with weight loss?

Although a study of obese mice found that berberine reduced weight and food intake, clinical trials in people haven’t shown meaningful weight loss.

A recent systematic review and meta-analysis of 12 randomized controlled trials found that berberine helped people, on average, lose about four and a half pounds and less than half an inch from their waist — results that Wilson said are “not exactly impressive.” Trials included in the review used different doses of berberine for about one to three months. The analysis has also been met with skepticism because the studies included are of low quality, and the team of researchers behind it have been flagged over data concerns.


Berberine isn’t strong enough to facilitate weight loss on its own, said Nikka Kanani, a Costa Mesa, Calif., practitioner licensed in naturopathic medicine. Proper diet and exercise are always most important in any weight loss journey, no matter if herbal supplements are involved.

Weight loss that occurs while taking berberine is really a “happy byproduct” of its effect on other factors, Kanani added. Lowering blood sugar, for example, will decrease the amount of glucose that is stored as body fat.

“Berberine is not to be thought of as a weight loss herb. It’s never been used that way and it’s never going to be because that’s not its mechanism of action,” said Amy Rothenberg, a Northampton, Mass., practitioner licensed in naturopathic medicine. “Can it be a component related to improving insulin sensitivity? Absolutely. But is your diet more important? 100 percent.”


Berberine’s long-term effects on weight loss are also unclear, Wilson said. “Weight loss, no matter how you’re achieving it, is notoriously hard to maintain. Are you supposed to take berberine, or even Ozempic, forever to keep the weight off? We just don’t know.”

How does berberine differ from Ozempic?

The mechanisms behind berberine and Ozempic could not be more different, experts said.

Ozempic, one of the brand names for semaglutide, reduces appetite and makes people feel full by mimicking the GLP-1 hormone that the gastrointestinal tract releases in response to eating. It also helps the body produce more insulin, which reduces blood sugar. Berberine increases the uptake of glucose by muscle fibers and improves insulin sensitivity by activating AMP-activated protein kinase (AMPK).

If anything, Wilson says, “berberine is ‘nature’s metformin,” which is a drug used to treat Type 2 diabetes that works via the same AMPK pathway.

What are the side effects of taking berberine supplements?

Berberine most commonly causes GI upset, including diarrhea, constipation and gas. If these symptoms persist for more than two weeks, you should stop taking berberine. In more serious cases, the supplement can cause nausea and vomiting if doses are too high, Rothenberg said, as well as neurologic symptoms such as tingling of the hands and feet, although these are rare.


The potential for sensitivity or an allergic reaction to berberine, or any supplement or medication, is also possible, Rothenberg warned.

Who should not take berberine?

People who are pregnant or breastfeeding should not take berberine because it can cross the placenta and breastmilk, respectively, and potentially harm newborn infants.

The supplement may slow the removal of a chemical called bilirubin (a byproduct of the breakdown of old red blood cells) from the liver, causing a rare type of brain damage called kernicterus. Infants born with high levels of bilirubin (jaundice) face greater risks if exposed to berberine.

People taking certain medications should also be wary of berberine. The supplement can affect how the liver breaks down some drugs, which could enhance their effects. Taking berberine alongside diabetes medications, for example, might lower blood sugar too much. The same idea applies to mixing berberine with anticoagulants and medications for hypertension.


“There could be more potential interactions with other medications, but there’s just not enough data,” Kanani said. “When something blows up like this, we're almost playing catch up.”

Are berberine supplements regulated by the FDA?

Companies that sell supplements don’t have to prove that their products are safe or effective before going on the market. The Food and Drug Administration only steps in to review a product if safety concerns arise.

The lack of regulation also means that supplements could contain “other fillers and compositional ingredients,” such as stimulants, that could interact poorly with other drugs, said Jennifer Lee, a scientist studying gut health and function at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

When it comes to vitamins and supplements, you will want to check if they are verified by the US Pharmacopeia (USP), Wilson said, which conducts independent lab testing on certain products to ensure the quality of their ingredients.


None of the experts we spoke to were aware of berberine supplements with USP certification.

“There have been many waves of new therapeutics and supplements for weight loss that seem all the rage, but time tells all truths in a sense,” Lee said. “Social media doesn’t offer the full picture, and there’s still no one hit wonder that can safely and effectively help people lose weight.

Do you have a question about healthy eating? Email EatingLab@washpost.com and we may answer your question in a future column.

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Why a trendy weight-loss supplement is not ‘nature’s Ozempic’ (2024)


Why a trendy weight-loss supplement is not ‘nature’s Ozempic’? ›

The term 'nature's Ozempic' is pure marketing, and implies that the berberine chemical is similar in any shape, form, or mechanism to Ozempic, and it's not,” said F. Perry Wilson, a Yale School of Medicine physician and epidemiologist who studies the supplement industry.

What is a natural alternative to Ozempic? ›

For people wanting an effective weight loss aid without the risks and high costs of medications like Ozempic, Zotrim is an excellent alternative. Its natural herbal formula inhibits hunger in a safe, sustainable way to facilitate weight loss over time.

Does berberine do the same thing as Ozempic? ›

Berberine may enhance the body's natural production of GLP-1, or glucagon-like peptide 1, a gastrointestinal hormone that's used in Ozempic and other new weight loss drugs. That's how the compound “fits into this discussion. However, in terms of its weight loss benefits, they are modest at best,” he said.

Why is Ozempic not approved for weight loss? ›

Ozempic is only intended and approved for people with type 2 diabetes. You should not take it solely for weight loss. Doing so may prevent patients who require the medication for blood sugar management from getting it. Interrupting their treatment with Ozempic creates serious health risks.

Is berberine better than Ozempic for weight loss? ›

2) By comparison, semaglutide (Ozempic) in clinical trials resulted in more weight loss overall relative to the weight loss data seen with berberine. However, both may have some negative side effects to consider and should be discussed with your doctor before deciding what's right for you.

What can I take for weight loss instead of Ozempic? ›

Saxenda (liraglutide)

Saxenda is FDA-approved for chronic weight management. It also improves blood sugar control, although it is not FDA-approved to treat type 2 diabetes. Unlike Ozempic, Saxenda is a daily injection for weight loss.

What over the counter is comparable to Ozempic? ›

  • PhenQ is a nutritious weight reduction product that works exclusively in the most efficient manner for everyone. ...
  • PhenGold is a weight reduction Ozempic Weight Loss Alternative and is both effective and beneficial. ...
  • Trimtone is the finest and most effective appetite suppressant.
Jun 14, 2023

Why don t doctors prescribe berberine? ›

Berberine can interact with prescription medications and increase or decrease levels of these medicines in the blood due to its effects on specific enzymes in the blood.

How quickly do you lose weight with berberine? ›

Body fats were reduced by 3.6% before and after treatment with berberine. The study findings showed that in just three months with berberine alone as the intervention, participants may reduce at least 5 pounds. Interestingly, the study revealed that blood lipid levels were reduced significantly.

Why can't you take berberine long term? ›

For decades it has been a well-researched herbal treatment for intestinal infections, like Giardia, but it came with the warning to avoid long-term use due to the potential undesirable and antimicrobial effect in the gut. Significant gastrointestinal side effects are well documented with berberine extract studies.

What is the controversy with Ozempic? ›

The medication requires a medical prescription, although people desperate to lose weight can buy it illegally. The high demand for Ozempic, combined with alleged supply and distribution issues, has occasionally deprived diabetics who truly need the drug.

How long can you stay on Ozempic for weight loss? ›

A person can stay on Ozempic® so long as they are tolerating the medication and it is deemed appropriate by their treating provider. There is no specific time frame when someone should stop taking Ozempic as it is a medication that is intended for chronic (long-term) use.

Why won't insurance pay for Ozempic? ›

In the absence of manufacturer coupons, drugs like Ozempic, Mounjaro, and Wegovy can be cost prohibitive, even for people with insurance. Because Ozempic and Mounjaro are indicated for diabetes, not weight loss on its own, insurance is unlikely to cover the cost if you don't have diabetes.

Has anyone lost weight with berberine? ›

One study carried out in 2012, found that taking 500 milligrams of berberine three times per day caused approximately 5 pounds of weight loss, on average, and helped participants lose 3.6% of their body fat.

Does anyone lose weight with berberine? ›

In some studies, berberine helped women with PCOS control their cholesterol, lower their waist-to-hip ratio, and increase their response to insulin. While berberine is not a magic weight-loss pill, it may help people with a body mass index (BMI) over 30 lose weight.

Can I take berberine just for weight loss? ›

Should I take berberine alone or in combination with diet and exercise? Currently, two studies have shown that intake of berberine alone in those who are clinically obese can result in significant weight loss. Intake of berberine should be done for at least three months to see visible results.

What happens when you stop taking Ozempic? ›

If you stop taking Ozempic, the weight you lost will likely return, fast. People who ceased use of semaglutide gained back, on average, a full two-thirds of the weight they had lost on the drug within one year, according to an August 2022 study, the Wall Street Journal reports.

Can I stop Ozempic cold turkey? ›

For most people, stopping Ozempic (or any medication that's meant to be taken long term) abruptly without a medical reason is not ideal. Stopping Ozempic is not directly harmful, but you may begin to notice weight gain.

How much weight can you lose with berberine? ›

Berberine can result in some modest weight-loss. A 2020 meta-analysis found that when people took about 500 mg of berberine daily, they lost just about four pounds on average, even when sticking with the regimen for months.

What foods are high in berberine? ›

What foods contain berberine? Berberine is found in the roots, leaves, stems, and bark of plants such as barberry, Oregon grape, and tree turmeric. It is uncommon to find these plants at your local supermarket in the United States, which is why berberine is usually taken in supplement form.


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